WIRRAL found unbeaten Tyldesley too strong as they lost interest in the EDF Energy Senior Vase.
It finished 20-5 to the visitors, who scored three tries, a conversion and a penalty. Wirral managed a consolation try from Adam Stephens.
Hoylake cruised through 89-0 at the expense of Wigton Wanderers. They scored 15 tries including one on his debut for Joe Lavin in a one-sided affair.
Widnes had no problems against visiting North Ribblesdale in a 29-7 outcome, but Ormskirk went out 12-23 at Winnington Park.
Sefton finished 23-17 to the good at Wallasey in a re-arranged South Lancashire/Cheshire Two encounter.
Paul Haines, Paul Thompson and Martin Sutton crossed for Wallasey with Matt Climo goaling once.
Brian Gardner went in twice for Sefton and John Evans once. John Fenton proved the match-winner with two penalties and one conversion.
