TRANMERE posted their first totesport.comLeague win in more than two months as a reserve team line-up with plenty of experience proved too strong for Oldham.
Rovers, a goal down early on, levelled on 24 minutes through full-back Aaron Cresswell.
Youth trainee Jay Ashcroft put the visitors ahead on 55 minutes and Kithson Bain secured the points with a third on 70 minutes. The hosts added another five minutes from time.
TRANMERE: Coughlin, Mackreth, Ashcroft, Benson, Cresswell, Barnett, Mahon, Shuker, Macauley, Bain, Gornell.
